NCC-MPNST3-X2-C1

Description

Cell line name NCC-MPNST3-X2-C1
Synonyms NCCMPNST3X2C1
Accession CVCL_YU15
Resource Identification Initiative To cite this cell line use: NCC-MPNST3-X2-C1 (RRID:CVCL_YU15)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia – CCLE).
Part of: NCC sarcoma cell line panel.
Population: Japanese.
Characteristics: Established from a second generation xenograft established by subcutaneous grafting of tumor tissue into the bilateral hind flanks of female NOD/Shi-scid IL-2Rgammanull mice.
Doubling time: 64 hours (PubMed=32099531).
Sequence variations
Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=32099531).
Mutation; HGNC; 7765; NF1; Simple; p.Arg816Ter (c.2446C>T); ClinVar=VCV000280055; Zygosity=Heterozygous (PubMed=32099531).
Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Unspecified (PubMed=32099531).
Mutation; HGNC; 11998; TP53; Simple; p.Cys135Trp (c.405C>G); ClinVar=VCV000376561; Zygosity=Heterozygous (PubMed=32099531).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_YU14 ! NCC-MPNST3-C1
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile

Source(s): PubMed=32099531

Markers:

Publications
PubMed=32099531; DOI=10.1186/s12935-020-1128-z
Oyama R., Kito F., Takahashi M., Hattori E., Noguchi R., Takai Y., Sakumoto M., Qiao Z., Toki S., Sugawara M., Tanzawa Y., Kobayashi E., Nakatani F., Iwata S., Yoshida A., Kawai A., Kondo T.
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors.
Cancer Cell Int. 20:58.1-58.15(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YU15
DepMap; ACH-002802
Encyclopedic resources Wikidata; Q95992537