NCC-MPNST4-C1

Description

Cell line name NCC-MPNST4-C1
Synonyms NCCMPNST4C1
Accession CVCL_YU16
Resource Identification Initiative To cite this cell line use: NCC-MPNST4-C1 (RRID:CVCL_YU16)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia – CCLE).
Part of: NCC sarcoma cell line panel.
Population: Japanese.
Doubling time: 70 hours (PubMed=32099531).
Sequence variations
Gene deletion; HGNC; 646; ARAF; Zygosity=Homozygous (PubMed=32099531).
Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=32099531).
Gene deletion; HGNC; 12637; KDM6A; Zygosity=Homozygous (PubMed=32099531).
Mutation; HGNC; 7765; NF1; Simple; c.5812+3delAGTA; Zygosity=Heterozygous (PubMed=32099531).
Mutation; HGNC; 11998; TP53; Simple; p.Arg249Gly (c.745A>G); ClinVar=VCV000376654; Zygosity=Homozygous (PubMed=32099531).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile

Source(s): PubMed=32099531

Markers:

Publications
PubMed=32099531; DOI=10.1186/s12935-020-1128-z
Oyama R., Kito F., Takahashi M., Hattori E., Noguchi R., Takai Y., Sakumoto M., Qiao Z., Toki S., Sugawara M., Tanzawa Y., Kobayashi E., Nakatani F., Iwata S., Yoshida A., Kawai A., Kondo T.
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors.
Cancer Cell Int. 20:58.1-58.15(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YU16
DepMap; ACH-002803
Encyclopedic resources Wikidata; Q95992538